L‑methylfolate
L‑methylfolate explained
L‑Methylfolate is the active folate form used to support folate status and as adjunctive therapy for mood under clinical guidance.
Not FDA ApprovedL‑methylfolate helps treat
• Folate deficiency
• Adjunctive mood support (with clinician)
• Homocysteine balance
additional medications
• Dietary folate (leafy greens, legumes)
• B‑complex with B12
• Medical guidance for dosing
medication risks
• May mask B12 deficiency—check B12
• Interactions with antifolate drugs
side effects
• Nausea
• GI upset
• Irritability (rare)
FAQs
Q: Supplement vs prescription?A: Prescription L‑methylfolate exists; supplements are not FDA‑approved drugs.
Q: Masking B12 deficiency?
A: High folate can mask B12 deficiency—check B12 if supplementing folate.
Q: Pregnancy?
A: Discuss prenatal folate needs and forms with an OB/GYN.
Q: Interactions?
A: May interact with certain antiepileptics or methotrexate protocols.
Q: Genetics (MTHFR)?
A: Active folate form may be preferred by some with MTHFR variants.
