Sertraline (Zoloft)
Sertraline (Zoloft) explained
Sertraline (Zoloft) is an SSRI antidepressant commonly prescribed for depression and several anxiety-related conditions. It helps increase serotonin levels in the brain and is widely used due to its efficacy and safety profile.
FDA ApprovedSertraline (Zoloft) helps treat
• Major depressive disorder (MDD)
• Obsessive–compulsive disorder (OCD)
• Panic disorder
• Post‑traumatic stress disorder (PTSD)
• Social anxiety disorder
• Premenstrual dysphoric disorder (PMDD)
• Generalized anxiety disorder (off‑label)
• Body dysmorphic disorder (off‑label)
• Premature ejaculation (off‑label)
• Irritable bowel syndrome (off‑label)
additional medications
• Other SSRIs (e.g., escitalopram, fluoxetine, citalopram, paroxetine)
• SNRIs (e.g., venlafaxine, duloxetine)
• Bupropion
• Mirtazapine
• Psychotherapy (CBT, ERP for OCD)
• Lifestyle: sleep, exercise, alcohol moderation (adjunct)
medication risks
• Black box warning: increased risk of suicidal thoughts/behaviors in young people
• Serotonin syndrome risk (especially with MAOIs, linezolid, triptans, St. John’s wort)
• Hyponatremia/SIADH (elderly risk higher)
• Bleeding risk when combined with NSAIDs/anticoagulants
• QT prolongation risk is generally low but caution with other QT‑prolonging drugs
• Activation of mania/hypomania in bipolar disorder
side effects
• Nausea, diarrhea
• Insomnia or somnolence
• Sexual dysfunction (libido changes, delayed ejaculation)
• Sweating, tremor
• Dizziness, headache
• Dry mouth
FAQs
Q: What is sertraline used for?A: Primarily for MDD, OCD, panic disorder, PTSD, social anxiety disorder, and PMDD.
Q: How long does sertraline take to work?
A: Mood and anxiety symptoms often improve within 2–4 weeks; full effect can take 6–8 weeks.
Q: Can I stop sertraline suddenly?
A: No. Taper with your clinician to reduce withdrawal symptoms.
Q: Are there serious risks?
A: All antidepressants carry a suicidality warning for young people; rare serotonin syndrome; hyponatremia.
Q: Is sertraline safe in pregnancy?
A: Discuss risks/benefits with your clinician; some risks exist, but untreated depression also has risks.
