Trazodone
Trazodone explained
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) approved for major depressive disorder. At lower doses it is commonly used off‑label for insomnia due to its sedating properties.
FDA ApprovedTrazodone helps treat
• Major depressive disorder (MDD)
• Insomnia (off‑label)
• Anxiety disorders (off‑label)
• Agitation in dementia (off‑label)
additional medications
• Other sleep strategies: CBT‑I (first‑line)
• Doxepin (low‑dose), suvorexant, lemborexant
• Melatonin, ramelteon
• Mirtazapine (sedating antidepressant)
medication risks
• Black box warning: suicidality risk in young people
• Serotonin syndrome (especially with MAOIs/serotonergic drugs)
• Priapism (rare urologic emergency)
• Orthostatic hypotension and falls
• Cardiac arrhythmias/QT prolongation (caution with risk factors)
• CNS depression—additive with alcohol/other sedatives
side effects
• Drowsiness, dizziness
• Dry mouth
• Headache
• Nausea
• Blurred vision
• Constipation or diarrhea
FAQs
Q: What is trazodone used for?A: Approved for depression; widely prescribed off‑label for insomnia.
Q: Is trazodone habit‑forming?
A: It is not a controlled substance, but abrupt changes can cause withdrawal‑like symptoms.
Q: Can I combine trazodone with other sleep aids?
A: Avoid mixing without medical advice; additive sedation and breathing risks may occur.
Q: How long before bed should I take it for sleep?
A: Usually 30–60 minutes before bedtime when used off‑label for insomnia.
Q: Are there serious risks?
A: Priapism (rare), serotonin syndrome with serotonergic drugs, arrhythmias in at‑risk patients.
