Paroxetine (Paxil)
Paroxetine (Paxil) explained
Paroxetine (Paxil) is an SSRI indicated for depression, multiple anxiety disorders, PTSD, and PMDD. It can be more sedating and has notable discontinuation symptoms if stopped abruptly.
FDA ApprovedParoxetine (Paxil) helps treat
• Major depressive disorder (MDD)
• Generalized anxiety disorder (GAD)
• Social anxiety disorder
• Panic disorder
• Obsessive–compulsive disorder (OCD)
• Post‑traumatic stress disorder (PTSD)
• Premenstrual dysphoric disorder (PMDD)
• Vasomotor symptoms of menopause (paroxetine mesylate 7.5 mg)
additional medications
• Other SSRIs (sertraline, escitalopram, fluoxetine, citalopram)
• SNRIs (venlafaxine, duloxetine)
• Bupropion, mirtazapine
• Psychotherapy (CBT)
medication risks
• Black box warning: suicidality risk in young people
• Serotonin syndrome risk
• Discontinuation syndrome if stopped abruptly
• Hyponatremia/SIADH
• Bleeding risk with NSAIDs/anticoagulants
• Potential congenital risk signals—consult OB/GYN if pregnant
side effects
• Nausea, drowsiness
• Sexual dysfunction
• Weight gain
• Dry mouth, sweating
• Constipation or diarrhea
• Dizziness
FAQs
Q: What is paroxetine used for?A: MDD, GAD, SAD, PD, OCD, PTSD, and PMDD; a low‑dose form treats hot flashes.
Q: Why is tapering important?
A: Paroxetine has a short half‑life and can cause significant discontinuation symptoms if stopped quickly.
Q: Does it cause weight gain or sedation?
A: Both can occur more often than with some other SSRIs.
Q: Is it safe in pregnancy?
A: Discuss with your clinician; certain risks have been reported with first‑trimester exposure.
Q: Any key interactions?
A: Avoid with MAOIs and caution with other serotonergic agents.
