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Clomipramine (Anafranil)

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Clomipramine (Anafranil) explained

Clomipramine (Anafranil) is a tricyclic antidepressant particularly effective for obsessive–compulsive disorder due to strong serotonergic activity.

FDA Approved

Clomipramine (Anafranil) helps treat

• Obsessive–compulsive disorder (OCD)
• Major depressive disorder (off‑label)
• Panic disorder (off‑label)

additional medications

• SSRIs (fluoxetine, sertraline)
• ERP therapy for OCD
• SNRIs

medication risks

• Suicidality warning in young people
• Cardiac conduction abnormalities
• Seizure risk at high doses
• Anticholinergic burden

side effects

• Dry mouth
• Constipation
• Blurred vision
• Drowsiness
• Weight gain
• Sweating

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FAQs

Q: What is clomipramine used for?
A: Primarily OCD; sometimes off‑label for depression/panic.

Q: Any heart risks?
A: TCAs can affect conduction—obtain cardiac history and consider ECG.

Q: Overdose risk?
A: TCAs can be dangerous in overdose—store safely.

Q: Anticholinergic effects?
A: Common—dry mouth, constipation, blurred vision.

Q: Sexual side effects?
A: Possible—varies by patient.

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