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5‑HTP

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5‑HTP explained

5‑HTP (5‑hydroxytryptophan) is a serotonin precursor used for mood and sleep support; it carries interaction risks with serotonergic medications.

Not FDA Approved

5‑HTP helps treat

• Low mood (adjunct; may support)
• Sleep quality
• Migraine support (some evidence)
• Appetite control (limited evidence)

additional medications

• Psychotherapy/CBT
• L‑tryptophan or melatonin (bedtime)
• Lifestyle: light exposure, sleep hygiene

medication risks

• Serotonin syndrome with serotonergic drugs
• May worsen mania in bipolar disorder
• Pregnancy/lactation: avoid unless advised

side effects

• Nausea
• Drowsiness
• Heartburn
• Vivid dreams

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FAQs

Q: Can I take with SSRIs/SNRIs?
A: No—risk of serotonin syndrome; only under medical supervision.

Q: Is 5‑HTP FDA‑approved?
A: No—supplements aren’t FDA‑approved for disease treatment.

Q: How long to notice effects?
A: Varies; weeks for mood/sleep outcomes.

Q: Any historical safety issues?
A: Contamination (EMS) occurred with L‑tryptophan in 1989; choose reputable brands.

Q: Take with food?
A: Often taken with food to reduce nausea.

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