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Aripiprazole (Abilify)

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Aripiprazole (Abilify) explained

Aripiprazole (Abilify) is a dopamine D2 partial agonist atypical antipsychotic used for schizophrenia, bipolar I, adjunctive MDD, and irritability in autism.

FDA Approved

Aripiprazole (Abilify) helps treat

• Schizophrenia
• Bipolar I mania/mixed
• Adjunctive therapy in MDD
• Irritability associated with autism

additional medications

• Lurasidone
• Quetiapine
• Cariprazine
• Psychotherapy/mood stabilizers as indicated

medication risks

• Akathisia/EPS
• Impulse‑control problems (rare warning)
• Neuroleptic malignant syndrome (rare)
• Tardive dyskinesia (long‑term)

side effects

• Akathisia (restlessness)
• Insomnia
• Nausea
• Headache
• Anxiety

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FAQs

Q: Why is aripiprazole different?
A: Partial agonism may reduce sedation and metabolic burden vs some others.

Q: Any movement risks?
A: Akathisia is relatively common; EPS can occur.

Q: Weight gain?
A: Usually modest but monitor metabolic markers.

Q: Use in depression?
A: Often as an adjunct when antidepressant response is inadequate.

Q: Long‑acting injectables?
A: Yes—LAI formulations are available.

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