Bupropion (Wellbutrin)
Bupropion (Wellbutrin) explained
Bupropion (Wellbutrin) is an NDRI antidepressant used for major depressive disorder and seasonal affective disorder; a sustained‑release form (Zyban) helps with smoking cessation.
FDA ApprovedBupropion (Wellbutrin) helps treat
• Major depressive disorder (MDD)
• Seasonal affective disorder (SAD)
• Smoking cessation (as bupropion SR/Zyban)
• ADHD (off‑label)
• SSRI‑related sexual dysfunction (off‑label)
additional medications
• SSRIs/SNRIs (sertraline, venlafaxine, duloxetine, escitalopram)
• Mirtazapine
• Psychotherapy (CBT)
• Light therapy (for SAD)
medication risks
• Black box warning: suicidality risk in young people
• Seizure risk (dose‑related; avoid in seizure/eating disorders)
• Hypertension (monitor)
• Angle‑closure glaucoma risk in susceptible patients
• Neuropsychiatric events with smoking cessation use
side effects
• Dry mouth
• Insomnia
• Headache
• Nausea
• Tremor
• Anxiety or agitation
FAQs
Q: What is bupropion used for?A: MDD and SAD; bupropion SR (Zyban) aids smoking cessation.
Q: Does bupropion cause sexual side effects?
A: It has a lower risk compared with SSRIs and may improve SSRI‑related dysfunction.
Q: Who should avoid bupropion?
A: People with seizure disorders or eating disorders due to higher seizure risk.
Q: Can it worsen anxiety?
A: Some feel jittery early on; dose adjustments can help.
Q: Any alcohol precautions?
A: Limit alcohol; abrupt cessation in heavy users raises seizure risk.
