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Glycine explained

Glycine is a simple amino acid used at bedtime to promote deeper, cooler sleep and next‑day alertness in some studies.

Not FDA Approved

Glycine helps treat

• Sleep quality and latency (may support)
• Core temperature regulation at night
• Calm and relaxation


additional medications

• CBT‑I
• Melatonin
• Magnesium

medication risks

• Additive sedation with other sleep aids (theoretical)
• Caution if on multiple CNS depressants

side effects

• GI upset
• Nausea
• Soft stools

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FAQs

Q: When to take?
A: 30–60 minutes before bed, often 3 g in studies.

Q: Is it sedating?
A: Usually gentle; many feel refreshed rather than groggy.

Q: Interactions?
A: Few known; check if using multiple sedatives.

Q: FDA approval?
A: No—supplements aren’t FDA‑approved to treat disease.

Q: Combine with?
A: Magnesium or L‑theanine for sleep routines.

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