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Imipramine (Tofranil)

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Imipramine (Tofranil) explained

Imipramine (Tofranil) is a tricyclic antidepressant for depression; also used for pediatric nocturnal enuresis (Tofranil PM).

FDA Approved

Imipramine (Tofranil) helps treat

• Major depressive disorder
• Nocturnal enuresis (pediatric)

additional medications

• SSRIs/SNRIs
• Behavioral strategies for enuresis
• Desmopressin (for enuresis)

medication risks

• Suicidality warning in young people
• Cardiac conduction abnormalities
• Anticholinergic burden

side effects

• Drowsiness
• Dry mouth
• Constipation
• Blurred vision
• Weight gain

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FAQs

Q: What is imipramine used for?
A: Depression and pediatric bed‑wetting.

Q: Cardiac effects?
A: TCAs can affect conduction—monitor if cardiac history.

Q: Overdose?
A: Potentially dangerous—store safely.

Q: Anticholinergic effects?
A: Common with TCAs.

Q: Sedation vs activation?
A: Often sedating, but varies by patient.

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