Ketamine (Off‑label: R/S‑ketamine)
Ketamine (Off‑label: R/S‑ketamine) explained
Ketamine is an NMDA receptor antagonist used off‑label at low doses for treatment‑resistant depression in certain programs. Unlike esketamine, IV/IM/SL ketamine is not FDA‑approved for depression.
Not FDA Approved (for depression)Ketamine (Off‑label: R/S‑ketamine) helps treat
• Treatment‑resistant depression (off‑label)
• Acute suicidal ideation (off‑label)
• Anesthesia (approved)
additional medications
• Esketamine (FDA‑approved)
• ECT/TMS
• Optimization of antidepressants and psychotherapy
medication risks
• Sedation/dissociation
• Transient hypertension
• Abuse/misuse potential
• Bladder toxicity with chronic/recreational use
side effects
• Dissociation
• Nausea
• Dizziness
• Headache
• Increased BP
• Anxiety
FAQs
Q: Is ketamine FDA‑approved for depression?A: No; only esketamine nasal spray is approved for depression.
Q: How is it administered off‑label?
A: IV/IM/SL/PO protocols vary by clinic; medical supervision required.
Q: How fast are effects?
A: Rapid onset in many patients; maintenance varies.
Q: Safety concerns?
A: Dissociation, BP rise, abuse potential; monitor closely.
Q: Can I drive after sessions?
A: Avoid driving until effects fully resolve, typically the next day.
