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Protriptyline (Vivactil)

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Protriptyline (Vivactil) explained

Protriptyline (Vivactil) is a tricyclic antidepressant with relatively activating properties, used for depression and sometimes for off‑label indications.

FDA Approved

Protriptyline (Vivactil) helps treat

• Major depressive disorder
• ADHD (off‑label)
• Apnea/respiratory stimulation (historic/rare)

additional medications

• SSRIs/SNRIs
• Bupropion
• Psychotherapy

medication risks

• Suicidality warning in young people
• Cardiac conduction abnormalities
• Anticholinergic burden

side effects

• Dry mouth
• Constipation
• Blurred vision
• Agitation/insomnia
• Dizziness

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FAQs

Q: What is protriptyline used for?
A: Depression; occasionally off‑label for other conditions.

Q: Stimulating vs sedating?
A: Often more activating than other TCAs.

Q: Cardiac concerns?
A: Like other TCAs, conduction abnormalities are possible.

Q: Overdose risk?
A: TCAs can be dangerous in overdose.

Q: Anticholinergic effects?
A: Yes—monitor for classic TCA side effects.

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