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Tranylcypromine (Parnate)

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Tranylcypromine (Parnate) explained

Tranylcypromine (Parnate) is an MAOI for treatment‑resistant depression. It is activating and requires tyramine dietary restrictions and careful drug interaction management.

FDA Approved

Tranylcypromine (Parnate) helps treat

• Major depressive disorder (treatment‑resistant)

additional medications

• Other antidepressants (with proper washout)
• Psychotherapy
• ECT for refractory cases

medication risks

• Hypertensive crisis with tyramine
• Serotonin syndrome with serotonergic drugs
• Orthostatic hypotension

side effects

• Insomnia
• Agitation
• Dizziness
• Headache
• Dry mouth

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FAQs

Q: What is tranylcypromine used for?
A: Depression unresponsive to other treatments.

Q: Diet considerations?
A: Avoid high‑tyramine foods to prevent hypertensive crisis.

Q: Interactions?
A: Contraindicated with many serotonergic/sympathomimetic drugs.

Q: Washouts?
A: Strict washouts when switching to/from MAOIs.

Q: Side effects vs Nardil?
A: Often more activating; individual responses vary.

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