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Valproate (Depakote)

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Valproate (Depakote) explained

Valproate (divalproex/valproic acid) is an anticonvulsant and mood stabilizer for seizures, bipolar mania, and migraine prophylaxis; carries boxed warnings for hepatotoxicity and teratogenicity.

FDA Approved

Valproate (Depakote) helps treat

• Seizure disorders
• Bipolar mania
• Migraine prophylaxis

additional medications

• Lamotrigine
• Lithium
• Carbamazepine
• Atypical antipsychotics (as indicated)

medication risks

• Hepatotoxicity (boxed)
• Pancreatitis (boxed)
• Teratogenicity (boxed)
• Thrombocytopenia

side effects

• Nausea
• Tremor
• Weight gain
• Hair loss
• Drowsiness

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FAQs

Q: What is valproate used for?
A: Seizures, bipolar mania, and migraine prevention.

Q: Pregnancy warning?
A: Strong teratogenic risk—avoid in pregnancy when possible.

Q: Lab monitoring?
A: LFTs, platelets; check levels when indicated.

Q: Weight gain?
A: Common—monitor metabolic health.

Q: Interactions?
A: Multiple—discuss with clinician/pharmacist.

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