Medications
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Imipramine (Tofranil)
Imipramine (Tofranil) is a tricyclic antidepressant for depression; also used for pediatric nocturnal enuresis (Tofranil PM).
Ketamine (Off‑label: R/S‑ketamine)
Ketamine is an NMDA receptor antagonist used off‑label at low doses for treatment‑resistant depression in certain programs. Unlike esketamine, IV/IM/SL ketamine is not FDA‑approved for depression.
Lamotrigine (Lamictal)
Lamotrigine (Lamictal) is an anticonvulsant and mood stabilizer used for seizures and bipolar I maintenance (especially depression prevention); requires slow titration to lower rash risk.
Lisdexamfetamine (Vyvanse)
Lisdexamfetamine (Vyvanse) is a prodrug stimulant for ADHD and binge eating disorder, offering smoother onset/offset and lower misuse risk versus some immediates.
Lorazepam (Ativan)
Lorazepam (Ativan) is a benzodiazepine used for acute anxiety, status epilepticus, and procedural sedation. It provides short‑term relief but has dependence and withdrawal risks.
Lurasidone (Latuda)
Lurasidone (Latuda) is an atypical antipsychotic indicated for schizophrenia and bipolar depression, often chosen for a more favorable metabolic profile; take with food.
Methylphenidate (Ritalin/Concerta)
Methylphenidate is a CNS stimulant for ADHD that improves attention and reduces impulsivity/hyperactivity; available in multiple immediate‑ and extended‑release forms.
Olanzapine (Zyprexa)
Olanzapine (Zyprexa) is an atypical antipsychotic for schizophrenia and bipolar disorder; effective but associated with significant weight gain and metabolic effects.
Paroxetine (Paxil)
Paroxetine (Paxil) is an SSRI indicated for depression, multiple anxiety disorders, PTSD, and PMDD. It can be more sedating and has notable discontinuation symptoms if stopped abruptly.
Phenelzine (Nardil)
Phenelzine (Nardil) is a monoamine oxidase inhibitor (MAOI) for treatment‑resistant depression and certain anxiety disorders; requires dietary restrictions to avoid hypertensive crisis.
Protriptyline (Vivactil)
Protriptyline (Vivactil) is a tricyclic antidepressant with relatively activating properties, used for depression and sometimes for off‑label indications.
Quetiapine (Seroquel)
Quetiapine (Seroquel) is an atypical antipsychotic for schizophrenia, bipolar disorder, and as adjunct for major depressive disorder (XR). Sedation and metabolic effects are common.
Risperidone (Risperdal)
Risperidone (Risperdal) is an atypical antipsychotic used for schizophrenia, bipolar mania, and irritability in autism; can raise prolactin and cause EPS at higher doses.
Sertraline (Zoloft)
Sertraline (Zoloft) is an SSRI antidepressant commonly prescribed for depression and several anxiety-related conditions. It helps increase serotonin levels in the brain and is widely used due to its efficacy and safety profile.
Tranylcypromine (Parnate)
Tranylcypromine (Parnate) is an MAOI for treatment‑resistant depression. It is activating and requires tyramine dietary restrictions and careful drug interaction management.
Trazodone
Trazodone is a serotonin antagonist and reuptake inhibitor (SARI) approved for major depressive disorder. At lower doses it is commonly used off‑label for insomnia due to its sedating properties.